Trimodal single-cell omics

A few different technologies have been demonstrated that enable high-throughput profiling of three modalities.

For instance, TEA-seq and DOGMA-seq enable gene expression, chromatin accessibility and surface protein profiling. NEAT-seq profiles nuclear proteins in addition to RNA and ATAC modalities.

The notebooks below demonstrate how to load and process some of these datasets:

• peripheral blood mononuclear cells (PBMCs) profiled with TEA-seq:

  1. loading, processing and integrating all three modalities.